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Details on Person CDT1-mediated loading of MCM2-7 to replication origin in budding yeast

Class:IdReaction:9749345
_displayNameCDT1-mediated loading of MCM2-7 to replication origin in budding yeast
_doReleaseTRUE
_timestamp2021-11-03 16:55:11
authored[InstanceEdit:9757622] Kusic-Tisma, Jelena, 2021-10-27
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9749344] Orlic-Milacic, Marija, 2021-08-01
edited[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
input[Complex:9749327] yORC(1-6):yCDC6:origin of replication [nucleoplasm] [Saccharomyces cerevisiae]
[Complex:9749307] yCDT1:yMCM2-7 [nucleoplasm] [Saccharomyces cerevisiae]
isChimericFALSE
literatureReference[LiteratureReference:9749309] An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly
[LiteratureReference:9749250] Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
modified[InstanceEdit:9757626] Orlic-Milacic, Marija, 2021-11-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCDT1-mediated loading of MCM2-7 to replication origin in budding yeast
output[Complex:9749343] yORC(1-6):yCDC6:origin of replication:yCDT1:yMCM2-7 [nucleoplasm] [Saccharomyces cerevisiae]
releaseDate2021-12-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:68322] Saccharomyces cerevisiae
stableIdentifier[StableIdentifier:9749347] R-SCE-9749345.2
summation[Summation:9749346] Based on yeast studies, CDT1 binding to the MCM2-7 complex i...
(inferredFrom)[Reaction:9749320] CDT1-mediated loading of MCM2-7 to replication origins [Homo sapiens]
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