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Details on Person While the simultaneous binding of CDT1 to the MCM2-7 complex...
| Class:Id | Summation:9749342 |
|---|---|
| _displayName | While the simultaneous binding of CDT1 to the MCM2-7 complex... |
| _timestamp | 2021-08-02 16:06:35 |
| created | [InstanceEdit:9749344] Orlic-Milacic, Marija, 2021-08-01 |
| literatureReference | [LiteratureReference:9749250] Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [LiteratureReference:9749309] An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly [LiteratureReference:9749277] Geminin inhibits a late step in the formation of human pre-replicative complexes [LiteratureReference:68713] Inhibition of eukaryotic DNA replication by geminin binding to Cdt1 |
| modified | [InstanceEdit:9749411] Orlic-Milacic, Marija, 2021-08-02 |
| text | While the simultaneous binding of CDT1 to the MCM2-7 complex and CDC6, as well as the interaction between MCM2-7 and CDC6 at the origin of replication was demonstrated in human cells (Wohlschlegel et al. 2000; Wu et al. 2014), the mechanism has been studied in detail only in the budding yeast (Sun et al. 2013; Fernández-Cid et al. 2013). Based on yeast studies, CDT1 binding to the MCM2-7 complex induces a structural change in the MCM2-7 that relieves MCM2-7 autoinhibition by the C-terminus of its MCM6 subunit, enabling a direct association between MCM2-7 and CDC6 bound to the ORC(1-6) complex at the replication origin (Fernández-Cid et al. 2013). As a result, the OCCM complex is formed, which contains ORC(1-6), CDC6, CDT1 and MCM2-7 bound to the replication origin (Fernández-Cid et al. 2013, Sun et al. 2013). The binding of geminin (GMNN) to CDT1 inhibits CDT1-mediated loading of the MCM2-7 complex to replication origins (Wohlschlegel et al. 2000). |
| (summation) | [Reaction:9749320] CDT1-mediated loading of MCM2-7 to replication origins [Homo sapiens] |
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