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Details on Person CDT1-mediated loading of MCM2-7 to replication origins

Class:Id	Reaction:9749320
_displayName	CDT1-mediated loading of MCM2-7 to replication origins
_doRelease	TRUE
_timestamp	2021-11-03 17:09:34
authored	[InstanceEdit:9757622] Kusic-Tisma, Jelena, 2021-10-27
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9749317] Orlic-Milacic, Marija, 2021-08-01
edited	[InstanceEdit:9757621] Orlic-Milacic, Marija, 2021-11-03
inferredFrom	[Reaction:9749345] CDT1-mediated loading of MCM2-7 to replication origin in budding yeast [Saccharomyces cerevisiae]
input	[Complex:9749216] ORC(1-6):CDC6:origin of replication [nucleoplasm] [Homo sapiens] [Complex:9749283] CDT1:MCM2-7 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9749277] Geminin inhibits a late step in the formation of human pre-replicative complexes [LiteratureReference:68713] Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
modified	[InstanceEdit:9749349] Orlic-Milacic, Marija, 2021-08-01 [InstanceEdit:9749355] Orlic-Milacic, Marija, 2021-08-01 [InstanceEdit:9749411] Orlic-Milacic, Marija, 2021-08-02 [InstanceEdit:9757626] Orlic-Milacic, Marija, 2021-11-03 [InstanceEdit:9757628] Orlic-Milacic, Marija, 2021-11-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDT1-mediated loading of MCM2-7 to replication origins
output	[Complex:9749318] ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9749286] CDT1 binds MCM2-7 [Homo sapiens] [Reaction:9749253] Formation of MCM2-7 complex [Homo sapiens] [Reaction:9749220] CDC6 binds ORC(1-6) [Homo sapiens] [BlackBoxEvent:8961619] CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex [Homo sapiens] [Reaction:9749215] MCM8 binds CDC6 [Homo sapiens]
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749340] R-HSA-9749320.2
summation	[Summation:9749342] While the simultaneous binding of CDT1 to the MCM2-7 complex...
(hasEvent)	[Pathway:68867] Assembly of the pre-replicative complex [Homo sapiens] [Pathway:9734667] (NEW) Assembly of the ORC complex at the origin of replication [Homo sapiens]
(precedingEvent)	[Reaction:9749350] ATP-dependent release of CDT1 from the OCCM complex [Homo sapiens]
(replacementInstances)	[_Deleted:9768317] Deletion of instance: 68826
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No pathways have been reviewed or authored by CDT1-mediated loading of MCM2-7 to replication origins (9749320)