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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person ORC1 binds to DNA at origin of replication sites

Class:IdReaction:9749098
_displayNameORC1 binds to DNA at origin of replication sites
_doReleaseTRUE
_timestamp2021-08-16 14:10:03
authored[InstanceEdit:9750783] Kusic-Tisma, Jelena, 2021-07-30
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9749097] Orlic-Milacic, Marija, 2021-07-30
edited[InstanceEdit:9750784] Orlic-Milacic, Marija, 2021-08-16
input[EntityWithAccessionedSequence:68522] ORC1 [nucleoplasm] [Homo sapiens]
[GenomeEncodedEntity:9749102] origin of replication [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9749122] Investigation of the Interaction of Human Origin Recognition Complex Subunit 1 with G-Quadruplex DNAs of Human c-myc Promoter and Telomere Regions
[LiteratureReference:9749131] Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs
[LiteratureReference:9749141] Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA
[LiteratureReference:9749166] Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells
[LiteratureReference:9749173] Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC-origin binding
[LiteratureReference:9749171] A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association
[LiteratureReference:9749181] Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing
[LiteratureReference:9749188] The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
modified[InstanceEdit:9749108] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749129] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749140] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749157] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749170] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749178] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749187] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749191] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9749201] Orlic-Milacic, Marija, 2021-07-30
[InstanceEdit:9750784] Orlic-Milacic, Marija, 2021-08-16
[InstanceEdit:9750805] Orlic-Milacic, Marija, 2021-08-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameORC1 binds to DNA at origin of replication sites
output[Complex:9749101] ORC1:origin of replication [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9749193] Positive regulation by 'ORC1:H4K20Me2-nucleosome'
releaseDate2021-09-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9749099] R-HSA-9749098.2
summation[Summation:9749124] Human ORC1 can associate with DNA origin of replication site...
(hasEvent)[Pathway:68616] Assembly of the ORC complex at the origin of replication [Homo sapiens]
[Pathway:9734667] (NEW) Assembly of the ORC complex at the origin of replication [Homo sapiens]
(precedingEvent)[Reaction:68611] Formation of ORC(1-5) complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775292] Update Tracker - [Reaction:9749098] ORC1 binds to DNA at origin of replication sites - v79:[modifyText]
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No pathways have been reviewed or authored by ORC1 binds to DNA at origin of replication sites (9749098)
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