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Details on Person TPMT transfers methyl group to 6TIMP, forming 6MeTIMP

Class:Id	Reaction:9748979
_displayName	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP
_doRelease	TRUE
_timestamp	2021-10-19 12:36:31
authored	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
catalystActivity	[CatalystActivity:158629] thiopurine S-methyltransferase activity of TPMT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
edited	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
goBiologicalProcess	[GO_BiologicalProcess:8768] xenobiotic catabolic process
input	[SimpleEntity:9748992] 6TIMP [cytosol] [SimpleEntity:71284] AdoMet [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9750256] Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties
modified	[InstanceEdit:9749777] Jassal, Bijay, 2021-08-05 [InstanceEdit:9750269] Jassal, Bijay, 2021-08-11 [InstanceEdit:9750573] Jassal, Bijay, 2021-08-16 [InstanceEdit:9755271] Jassal, Bijay, 2021-10-07 [InstanceEdit:9756882] Jassal, Bijay, 2021-10-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP 6TIMP--TPMT-->6MeTIMP
output	[SimpleEntity:9748944] 6MeTIMP [cytosol] [SimpleEntity:71285] AdoHcy [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP [Homo sapiens] [Reaction:9748996] GST dimers cleave AZA to 6MP [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749015] R-HSA-9748979.2
summation	[Summation:9750561] Thiopurine methyltransferase (TPMT) can methylate thiopurine...
(hasEvent)	[Pathway:9748787] Azathioprine ADME [Homo sapiens]
(precedingEvent)	[Reaction:9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region [Homo sapiens] [Reaction:9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (9748979)