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Details on Person HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP

Class:Id	Reaction:9748951
_displayName	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP
_doRelease	TRUE
_timestamp	2021-10-19 12:35:47
authored	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
catalystActivity	[CatalystActivity:74210] purine phosphoribosyltransferase activity of HPRT1 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
edited	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
input	[ChemicalDrug:9748998] 6MP [cytosol] [SimpleEntity:73566] PRPP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9750291] Human hypoxanthine phosphoribosyltransferase. I. Purification, properties, and specificity [LiteratureReference:9750290] Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: rapid phosphoribosyl transfer chemistry
modified	[InstanceEdit:9749777] Jassal, Bijay, 2021-08-05 [InstanceEdit:9750285] Jassal, Bijay, 2021-08-11 [InstanceEdit:9755271] Jassal, Bijay, 2021-10-07 [InstanceEdit:9756882] Jassal, Bijay, 2021-10-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP 6MP--HPRT1-->6TIMP
output	[SimpleEntity:9748992] 6TIMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:9748996] GST dimers cleave AZA to 6MP [Homo sapiens]
releaseDate	2021-12-08
reviewed	[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9749011] R-HSA-9748951.2
summation	[Summation:9750293] 6-mercaptopurine (6MP) can be metabolized via three competin...
(hasEvent)	[Pathway:9748787] Azathioprine ADME [Homo sapiens]
(precedingEvent)	[Reaction:9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP [Homo sapiens] [Reaction:9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP [Homo sapiens] [Reaction:9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region [Homo sapiens] [Reaction:9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (9748951)