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Details on Person After initial activation of Nkx2-5 and Gata4 by Mesp1, Gata4...
| Class:Id | Summation:9748876 |
|---|---|
| _displayName | After initial activation of Nkx2-5 and Gata4 by Mesp1, Gata4... |
| _timestamp | 2022-02-04 15:36:18 |
| created | [InstanceEdit:9748891] May, Bruce, 2021-07-28 |
| modified | [InstanceEdit:9749090] May, Bruce, 2021-07-30 [InstanceEdit:9749852] May, Bruce, 2021-08-06 [InstanceEdit:9763741] May, Bruce, 2022-02-04 |
| text | After initial activation of Nkx2-5 and Gata4 by Mesp1, Gata4 binds the promoter of the Nkx2-5 gene and activates transcription (Lien et al. 1999, Reecy et al. 1999, Brown et al. 2004, He et al. 2011, He et al. 2014). Smad1:Smad4 complexes that are apparently activated by Bmp signaling also bind the Nkx2-5 promoter, recruit Gata4, and synergistically enhance transcription (Brown et al. 2004). In the second heart field (SHF) Mef2c mediates the binding of Nkx2-5 to its own promoter (Clark et al. 2013). Tbx20 binds the cardiac enhancer of the Nkx2-5 promoter and activates transcription (Takeuchi et al. 2005) |
| (summation) | [Reaction:9734336] Gata4, Smad1:Smad4, Mef2c, Tbx20, and Nkx2-5 bind the Nkx2-5 gene [Mus musculus] |
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No pathways have been reviewed or authored by After initial activation of Nkx2-5 and Gata4 by Mesp1, Gata4... (9748876)
