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Details on Person Thrombin-, ROCK1- and integrin-mediated release of active TGFB1

Class:IdBlackBoxEvent:9748694
_displayNameThrombin-, ROCK1- and integrin-mediated release of active TGFB1
_doReleaseFALSE
_timestamp2021-07-26 13:47:34
compartment[Compartment:984] extracellular region
created[InstanceEdit:9748693] Orlic-Milacic, Marija, 2021-07-26
input[Complex:2396201] LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane] [Homo sapiens]
isChimericFALSE
modified[InstanceEdit:9748709] Orlic-Milacic, Marija, 2021-07-26
nameThrombin-, ROCK1- and integrin-mediated release of active TGFB1
output[Complex:170852] Dimeric TGFB1 [extracellular region] [Homo sapiens]
[Complex:9748703] LTBP1:TGFB1:LAP1:LAP1-binding integrins:Fibronectin [plasma membrane] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9748706] Positive regulation by 'Thrombin:F2R [plasma membrane]'
[PositiveRegulation:9748704] Positive regulation by 'ROCK1,ROCK2 [cytosol]'
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9748695] R-HSA-9748694.1
(hasEvent)[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens]
[Pathway:9753549] TGF-beta ligand biogenesis, secretion and activation [Homo sapiens]
(precedingEvent)[Reaction:170861] Dimeric TGF-beta-1 binds to the receptor [Homo sapiens]
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No pathways have been reviewed or authored by Thrombin-, ROCK1- and integrin-mediated release of active TGFB1 (9748694)