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Details on Person CRL1 (FBXL2) polyubiquitinates NLRP3 at K689

Class:Id	BlackBoxEvent:9748671
_displayName	CRL1 (FBXL2) polyubiquitinates NLRP3 at K689
_doRelease	FALSE
_timestamp	2022-06-09 23:17:13
catalystActivity	[CatalystActivity:9748665] ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9748669] ubiquitin protein ligase activity of SCF(FBXL2) [cytosol] Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9748659] Shamovsky, Veronica, 2021-07-23
input	[EntityWithAccessionedSequence:561189] NLRP3 [cytosol] [Homo sapiens] [Complex:9748672] SKP1:CUL1:RBX1:FBXL2 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9748654] Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase [LiteratureReference:9793153] Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation
modified	[InstanceEdit:9750243] Shamovsky, Veronica, 2021-08-11 [InstanceEdit:9793159] Shamovsky, Veronica, 2022-06-06 [InstanceEdit:9793287] Shamovsky, Veronica, 2022-06-09
name	CRL1 (FBXL2) polyubiquitinates NLRP3 at K689
output	[Complex:9748660] SCF(FBXL2) complex:Ub-K689-NLRP3 [cytosol] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9748677] R-HSA-9748671.1
summation	[Summation:9748655] F-box/LRR-repeat protein 2 (FBXL2) is a component of a multi...
(hasEvent)	[Pathway:9712312] Regulation of NLRP3 inflammasome [Homo sapiens]
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No pathways have been reviewed or authored by CRL1 (FBXL2) polyubiquitinates NLRP3 at K689 (9748671)