Query author contributions in Reactome
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Details on Person UniProt:Q9Y5N6 ORC6
| Class:Id | ReferenceGeneProduct:97409 |
|---|---|
| _chainChangeLog | chain:1-252 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y5N6 ORC6 |
| _timestamp | 2026-02-20 21:32:52 |
| chain | chain:1-252 |
| checksum | 78840387605F45FE |
| comment | FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.SUBUNIT Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity).SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ORC6 family. |
| description | recommendedName: Origin recognition complex subunit 6 |
| geneName | ORC6 ORC6L |
| identifier | Q9Y5N6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant DNA replication DNA-binding Dwarfism Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORC6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994407] ENSEMBL:ENSG00000091651 ORC6 [Homo sapiens] |
| secondaryIdentifier | ORC6_HUMAN B3KN89 |
| sequenceLength | 252 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68539] ORC6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9734663] ORC6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9734682] p-T195-ORC6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9734715] p-T195-ORC6 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9734686] O-phospho-L-threonine at 195 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y5N6 ORC6 (97409)
