Query author contributions in Reactome
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Details on Person UniProt:O43913 ORC5
| Class:Id | ReferenceGeneProduct:97404 |
|---|---|
| _chainChangeLog | chain:1-435 added on Fri February 6 2015 |
| _displayName | UniProt:O43913 ORC5 |
| _timestamp | 2024-11-03 20:20:32 |
| chain | chain:1-435 |
| checksum | 0FEB0E829C124745 |
| comment | FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.SUBUNIT Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.INTERACTION Abundant in spleen, ovary, prostate, testis, and colon mucosa.PTM Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle.MISCELLANEOUS Does not interact with ORC2.SIMILARITY Belongs to the ORC5 family. |
| description | recommendedName: Origin recognition complex subunit 5 |
| geneName | ORC5 ORC5L |
| identifier | O43913 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Chromosome DNA replication Nucleotide-binding Nucleus Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ORC5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000224] ENSEMBL:ENSG00000164815 ORC5 [Homo sapiens] |
| secondaryIdentifier | ORC5_HUMAN A4D0P8 O60590 O95268 |
| sequenceLength | 435 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965726] UniProt:O43913-1 ORC5 [Homo sapiens] [ReferenceIsoform:8965727] UniProt:O43913-2 ORC5 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68516] ORC5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9735381] ORC5 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43913 ORC5 (97404)
