Query author contributions in Reactome
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Details on Person UniProt:O43929 ORC4
| Class:Id | ReferenceGeneProduct:97399 |
|---|---|
| _chainChangeLog | chain:1-436 added on Fri February 6 2015 |
| _displayName | UniProt:O43929 ORC4 |
| _timestamp | 2024-11-03 20:20:32 |
| chain | chain:1-436 |
| checksum | A7020B6690E30B4E |
| comment | FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.SUBUNIT Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with POLQ (PubMed:24989122).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ORC4 family. |
| description | recommendedName: Origin recognition complex subunit 4 |
| geneName | ORC4 ORC4L |
| identifier | O43929 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Disease variant DNA replication DNA-binding Dwarfism Methylation Nucleotide-binding Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ORC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999061] ENSEMBL:ENSG00000115947 ORC4 [Homo sapiens] |
| secondaryIdentifier | ORC4_HUMAN B7Z3D0 B7Z5F1 D3DP86 F5H069 Q96C42 |
| sequenceLength | 436 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977128] UniProt:O43929-1 ORC4 [Homo sapiens] [ReferenceIsoform:8977129] UniProt:O43929-2 ORC4 [Homo sapiens] [ReferenceIsoform:8977130] UniProt:O43929-3 ORC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68519] ORC4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9735390] ORC4 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43929 ORC4 (97399)
