Query author contributions in Reactome
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Details on Person UniProt:Q13415 ORC1
| Class:Id | ReferenceGeneProduct:97385 |
|---|---|
| _chainChangeLog | chain:1-861 added on Fri February 6 2015 |
| _displayName | UniProt:Q13415 ORC1 |
| _timestamp | 2024-11-03 19:53:00 |
| chain | chain:1-861 |
| checksum | 5C594553F7F808E2 |
| comment | FUNCTION Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.SUBUNIT Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.INTERACTION Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level).DOMAIN The BAH domain mediates binding to dimethylated histone H4 'Lys-20' (H4K20me2), which is enriched at replication origins.PTM Phosphorylated during mitosis.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ORC1 family. |
| description | recommendedName: Origin recognition complex subunit 1 alternativeName: Replication control protein 1 |
| geneName | ORC1 ORC1L PARC1 |
| identifier | Q13415 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Disease variant DNA replication DNA-binding Dwarfism Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ORC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2888909] ENSEMBL:ENSG00000085840 ORC1 [Homo sapiens] |
| secondaryIdentifier | ORC1_HUMAN D3DQ34 Q13471 Q5T0F5 |
| sequenceLength | 861 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68522] ORC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:68943] p-S,T-ORC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:113840] ORC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9032189] PolyUb,p-S,T-ORC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9032195] PolyUb,p-S,T-ORC1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:141611] O-phospho-L-threonine at unknown position [ModifiedResidue:141612] O-phospho-L-serine at unknown position [GroupModifiedResidue:9032190] ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q13415 ORC1 (97385)
