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Details on Person p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter

Class:Id	Reaction:9736984
_displayName	p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter
_doRelease	TRUE
_timestamp	2022-05-09 21:49:39
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9736986] Orlic-Milacic, Marija, 2021-07-15
edited	[InstanceEdit:9736980] Orlic-Milacic, Marija, 2021-07-15 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input	[EntityWithAccessionedSequence:2127254] MYC gene [nucleoplasm] [Homo sapiens] [Complex:2127250] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1484105] E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
modified	[InstanceEdit:9751106] Orlic-Milacic, Marija, 2021-08-18 [InstanceEdit:9751119] Orlic-Milacic, Marija, 2021-08-18 [InstanceEdit:9754418] Orlic-Milacic, Marija, 2021-09-24 [InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter
output	[Complex:9736985] p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2:MYC gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Homo sapiens] [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9736988] R-HSA-9736984.4
summation	[Summation:9736987] Complex formed by RBL1 (p107), E2F4/5, DP1/2 and a trimer of...
(hasEvent)	[Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1484099] MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex [Homo sapiens]
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No pathways have been reviewed or authored by p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter (9736984)