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Details on Person Severe acute respiratory syndrome coronavirus type 1 (SARS‑C...
| Class:Id | Summation:9735872 |
|---|---|
| _displayName | Severe acute respiratory syndrome coronavirus type 1 (SARS‑C... |
| _timestamp | 2021-07-23 12:53:21 |
| created | [InstanceEdit:9735870] Shamovsky, Veronica, 2021-07-05 |
| literatureReference | [LiteratureReference:9727871] Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling [LiteratureReference:9731055] The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway [LiteratureReference:9731064] The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling [LiteratureReference:9727920] Interactions of SARS coronavirus nucleocapsid protein with the host cell proteasome subunit p42 [LiteratureReference:9727889] SARS-CoV nucleocapsid protein binds to hUbc9, a ubiquitin conjugating enzyme of the sumoylation system [LiteratureReference:9731078] Severe acute respiratory syndrome coronavirus Orf3a protein interacts with caveolin |
| modified | [InstanceEdit:9737728] Shamovsky, Veronica, 2021-07-21 [InstanceEdit:9748608] Shamovsky, Veronica, 2021-07-23 |
| text | Severe acute respiratory syndrome coronavirus type 1 (SARS‑CoV‑1) encodes several proteins that modulate host intracellular signaling and regulatory pathways. Among them are nucleocapsid N, membrane M and 3a proteins that directly bind to host targets associated with SARS‑CoV‑1 infection and cytokine production. This Reactome module describes several such binding events and their consequences. First, SARS‑CoV‑1 M binds to 3‑phosphoinositide‑dependent protein kinase 1 (PDPK1) to inhibit PKB/Akt activation (Chan et al. 2007; Tsoi et al. 2014). Second, SARS‑CoV‑1 N binds to SMAD3 to alter transforming growth factor‑β (TGF‑β) signaling (Zhao et al. 2008). This interaction prevents SMAD3 from complexing with SMAD4, thereby blocking TGF-β-sensitized apoptosis. The association of N with SMAD3 also enhances the TGF-β-induced expression of PAI-1 (SERPINE1) promoting tissue fibrosis (Zhao et al. 2008). Third, N protein binding to proteasome subunit p42 (PSMC6) modulates proteasome‑regulated degradation of proteins (Wang et al. 2010). Fourth, SARS‑CoV‑1 N binds SUMO-conjugating enzyme UBC9 (UBE2I) to regulate the activity of UBE2I, affecting downstream signaling factors involved in the cell cycle, in addition to its function in the process of sumoylation (Fan et al. 2006). Finally, binding of viral 3a to the regulator and scaffolding protein caveolin‑1 (CAV1) may regulate virus uptake as well as the trafficking of viral structural proteins (Padhan et al. 2007). |
| (summation) | [Pathway:9735871] SARS-CoV-1 targets host intracellular signalling and regulatory pathways [Homo sapiens] |
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No pathways have been reviewed or authored by Severe acute respiratory syndrome coronavirus type 1 (SARS‑C... (9735872)
