Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person CASP1 autoproteolysis

Class:Id	BlackBoxEvent:9735702
_displayName	CASP1 autoproteolysis
_doRelease	FALSE
_timestamp	2021-06-29 21:23:48
catalystActivity	[CatalystActivity:9735709] cysteine-type endopeptidase activity of NLRP3 elicitors:NLRP3 oligomer:PYCARD oligomer:CASP1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9735707] cysteine-type endopeptidase activity of NLRP3 elicitors:NLRP3 oligomer:PYCARD oligomer:CASP1 [cytosol] Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9735699] Shamovsky, Veronica, 2021-06-29
input	[Complex:9735700] NLRP3 elicitors:NLRP3 oligomer:PYCARD oligomer:CASP1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:874043] The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
modified	[InstanceEdit:9735708] Shamovsky, Veronica, 2021-06-29
name	CASP1 autoproteolysis
output	[Complex:448691] Caspase-1 tetramer [cytosol] [Homo sapiens] [Complex:9712444] NLRP3 elicitors:NLRP3 oligomer:PYCARD oligomer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:844612] PYCARD recruits procaspase-1 via CARD [Homo sapiens] [Reaction:844610] NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction [Homo sapiens]
relatedSpecies	[Species:877180] Staphylococcus aureus
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9735704] R-HSA-9735702.1
summation	[Summation:9735701] Caspase-1 (CASP1) is a cysteine protease that induces inflam...
(hasEvent)	[Pathway:844456] The NLRP3 inflammasome [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by CASP1 autoproteolysis (9735702)