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Details on Person OSBP:CHOL:PTPN7:PP2A dephosphorylates p-T,Y-MAPKs

Class:Id	Reaction:9735132
_displayName	OSBP:CHOL:PTPN7:PP2A dephosphorylates p-T,Y-MAPKs
_timestamp	2021-09-20 18:32:15
catalystActivity	[CatalystActivity:9735107] non-membrane spanning protein tyrosine phosphatase activity of OSBP dimer:CHOL:PTPN7:PP2A [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9735133] Rothfels, Karen, 2021-06-21
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [DefinedSet:169289] p-T,Y MAPKs [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9735037] A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity [LiteratureReference:9735043] Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK) [LiteratureReference:9735040] OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation
modified	[InstanceEdit:9753999] Rothfels, Karen, 2021-09-20
name	OSBP:CHOL:PTPN7:PP2A dephosphorylates p-T,Y-MAPKs OSBP:CHOL:PTPN7:PP2A dephosphorylates ERKs
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [DefinedSet:169291] MAPKs [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9735131] OSBP binds CHOL, PTPN7 and PP2A [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9735134] R-HSA-9735132.1
summation	[Summation:9735088] A complex of OSBP and cholesterol scaffolds a dual-specifici...
(hasEvent)	[Pathway:5675221] Negative regulation of MAPK pathway [Homo sapiens]
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No pathways have been reviewed or authored by OSBP:CHOL:PTPN7:PP2A dephosphorylates p-T,Y-MAPKs (9735132)