Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Futile Cycle

Class:IdNegativePrecedingEventReason:9734985
_displayNameFutile Cycle
_timestamp2021-06-19 16:34:05
created[InstanceEdit:9734983] Wu, Guanming, 2021-06-19
definitionWhen a pair of cyclic reactions counter the effect of each other
nameFutile Cycle
(reason)[NegativePrecedingEvent:9754407] Futile Cycle: PARP1 ADP-ribosylates SMAD3 and SMAD4
[NegativePrecedingEvent:9754408] Futile Cycle: SMURF2 monoubiquitinates SMAD3
[NegativePrecedingEvent:9754409] Futile Cycle: Release of STAT1 dimer from active receptor unit
[NegativePrecedingEvent:9754410] Futile Cycle: Dephosphorylated SMAD2/3 translocates to the cytosol
[NegativePrecedingEvent:9754411] Futile Cycle: RNF111 ubiquitinates SMAD7
[NegativePrecedingEvent:9754412] Futile Cycle: USP9X (FAM) deubiquitinates SMAD4
[NegativePrecedingEvent:9754413] Futile Cycle: SMURF2 monoubiquitinates SMAD3
[NegativePrecedingEvent:9754414] Futile Cycle: TRIM33 monoubiquitinates SMAD4
[NegativePrecedingEvent:9754415] Futile Cycle: NEDD4L ubiquitinates SMAD2/3
[NegativePrecedingEvent:9754416] Futile Cycle: RNF111 ubiquitinates SMAD7
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No pathways have been reviewed or authored by Futile Cycle (9734985)