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Query author contributions in Reactome

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Details on Person PPARA binds fibrates

Class:IdReaction:9734475
_displayNamePPARA binds fibrates
_doReleaseTRUE
_timestamp2025-07-08 21:05:34
authored[InstanceEdit:9734465] Jassal, Bijay, 2021-06-17
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9734465] Jassal, Bijay, 2021-06-17
definitionAgonist|Agonist
edited[InstanceEdit:9734465] Jassal, Bijay, 2021-06-17
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input[DefinedSet:9734495] fibrates [nucleoplasm]
[Complex:400196] PPARA:RXRA:Corepressors [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:9734477] Discovery of gemfibrozil analogues that activate PPARĪ± and enhance the expression of gene CPT1A involved in fatty acids catabolism
[LiteratureReference:9734479] Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB
[LiteratureReference:9734497] Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii
[LiteratureReference:9732648] N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents
[LiteratureReference:9734507] Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells
[LiteratureReference:9734512] The biochemical pharmacology of fenofibrate
modified[InstanceEdit:9734514] Jassal, Bijay, 2021-06-17
[InstanceEdit:9734531] Jassal, Bijay, 2021-06-17
[InstanceEdit:9773229] Matthews, Lisa, 2022-05-03
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
[InstanceEdit:9773858] Matthews, Lisa, 2022-05-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08
namePPARA binds fibrates
output[Complex:9734456] PPARA:RXRA:fibrates [nucleoplasm] [Homo sapiens]
[DefinedSet:400207] Corepressors of PPARalpha [nucleoplasm] [Homo sapiens]
precedingEvent
reactionType[DrugActionType:9725061] Agonist
releaseDate2022-06-09
reviewed[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9734504] R-HSA-9734475.3
summation[Summation:9734517] The peroxisome proliferator-activated receptor alpha (PPARA)...
(hasEvent)[Pathway:400206] Regulation of lipid metabolism by PPARalpha [Homo sapiens]
(precedingEvent)[BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens]
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No pathways have been reviewed or authored by PPARA binds fibrates (9734475)
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