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Details on Person During normal digestion, bile salts are secreted into the in...
| Class:Id | Summation:9734231 |
|---|---|
| _displayName | During normal digestion, bile salts are secreted into the in... |
| _timestamp | 2021-06-16 13:59:22 |
| created | [InstanceEdit:9734221] Jassal, Bijay, 2021-06-16 |
| literatureReference | [LiteratureReference:9734224] Treatment of hypercholesterolaemia with colestipol: a bile sequestrating agent [LiteratureReference:9734226] Colestipol and cholestyramine resin. Comparative effects in familial type II hyperlipoproteinemia [LiteratureReference:9734237] A 50-week extension study on the safety and efficacy of colesevelam in adults with primary hypercholesterolemia [LiteratureReference:9734227] Colesevelam. GT 31104, CholestaGel |
| modified | [InstanceEdit:9734246] Jassal, Bijay, 2021-06-16 [InstanceEdit:9734247] Jassal, Bijay, 2021-06-16 [InstanceEdit:9734252] Jassal, Bijay, 2021-06-16 |
| text | During normal digestion, bile salts are secreted into the intestines. Around 95% of bile salts (and acids formed by the action of gut microflora) are absorbed from the intestinal tract and returned to the liver via enterohepatic circulation. Since cholesterol is a major constituent of bile acids and salts, these recirculation pathways can play an important role in cholesterol homeostasis. Bile acid/salt sequestrants are polymeric compounds which serve as ion exchange resins. These resins adsorb and combine with bile acids and salts in the intestine to form an insoluble complex which is excreted in the feces (Nichifor et al. 1998, Nichifor et al. 2001, Zhu et al. 1992). This limits the reabsorption of bile acids from the intestine and has the effect of lowering cholesterol levels as the liver has to produce new bile salts. The bile acid/salt sequestrants cholestyramine, colesevelam (No authors listed 1999) and colestipol (Parkinson et al. 1970) used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (Nye et al. 1972, Glueck et al. 1972, Davidson et al. 2010). |
| (summation) | [Reaction:9733975] Bile salts and acids bind bile acid/salt sequestrants [Homo sapiens] |
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No pathways have been reviewed or authored by During normal digestion, bile salts are secreted into the in... (9734231)
