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Details on Person Paramyxovirus V proteins target both IFIH1 (MDA5) and DHX58 ...

Class:IdSummation:9734038
_displayNameParamyxovirus V proteins target both IFIH1 (MDA5) and DHX58 ...
_timestamp2021-06-15 00:47:34
created[InstanceEdit:9734025] Shamovsky, Veronica, 2021-06-15
literatureReference[LiteratureReference:9734036] Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling
[LiteratureReference:9734042] Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition
[LiteratureReference:9734045] Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: a single arginine distinguishes MDA5 from RIG-I
[LiteratureReference:1237382] mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
[LiteratureReference:9734043] The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter
[LiteratureReference:9734046] A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2
textParamyxovirus V proteins target both IFIH1 (MDA5) and DHX58 (LGP2) helicase domains (Andrejeva J et al. 2004; Childs K et al. 2007; Rodriguez KR and Horvath CM 2013). Analysis of the interaction interface revealed the IFIH1 helicase C domain as necessary and sufficient for association with V proteins from human parainfluenza virus type 2, parainfluenza virus type 5 (PIV5), measles virus (MeV), mumps virus, Hendra virus, and Nipah virus (Parisien JP et al. 2009). Structural and biochemical studies showed that the viral V protein interaction disrupts ATP hydrolysis mediated by both IFIH1 and DHX58 (Parisien JP et al. 2009; Motz C et al. 2013). Expression of either MeV or PIV5 P/V protein antagonized IFIH1 (MDA5) signaling and also prevented DHX58 (LGP2)-mediated IFIH1 enhancement in human embryonic kidney 293 cells (Rodriguez KR and Horvath CM 2014). This Reactome event shows the ineraction of MeV P/V with both IFIH1 and DHX58.
(summation)[Reaction:9734035] MeV P/V binds IFIH1:DAK and DHX58 [Homo sapiens]
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