Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person After the cleavage of ACE2-bound SARS-CoV-2 Spike into S1 an...
| Class:Id | Summation:9733884 |
|---|---|
| _displayName | After the cleavage of ACE2-bound SARS-CoV-2 Spike into S1 an... |
| _timestamp | 2022-03-26 08:32:06 |
| created | [InstanceEdit:9733885] Stephan, Ralf, 2021-06-11 |
| modified | [InstanceEdit:9733901] Gillespie, Marc E, 2021-06-11 [InstanceEdit:9733902] Gillespie, Marc E, 2021-06-11 [InstanceEdit:9770068] Stephan, Ralf, 2022-03-24 [InstanceEdit:9770179] Stephan, Ralf, 2022-03-25 [InstanceEdit:9770211] Stephan, Ralf, 2022-03-26 |
| text | After the cleavage of ACE2-bound SARS-CoV-2 Spike into S1 and S2 both fragments dissociate from the S1:ACE2:S2 complex, exposing S2 to host endonucleases. In particular, the Spike RBDs on the S1 fragment trimer can bind to more than one ACE2 molecule which, after cleavage of S, can lead to dissociation of S1:ACE2 from S2, as well as the S1 trimer itself. This process is driven by a change in the RBD conformation from closed to open while bound to ACE2, leaving a trimeric ring of S1 molecules that are attached to the S2 core only through contacts with its two small intermediate subdomains (Benton et al, 2020; reviewed in Rey, 2021). |
| (summation) | [BlackBoxEvent:9770063] S1,S2 Dissociate from S1:ACE2:S2 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by After the cleavage of ACE2-bound SARS-CoV-2 Spike into S1 an... (9733884)
