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Details on Person YWHAE binds DDX58 and TRIM25

Class:Id	Reaction:9733680
_displayName	YWHAE binds DDX58 and TRIM25
_timestamp	2021-06-08 18:12:02
catalystActivityReference	[CatalystActivityReference:9643974] ubiquitin-protein transferase activity of RNF135,TRIM25 [cytosol] TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9733681] Shamovsky, Veronica, 2021-06-08
input	[Complex:168906] 2x DDX58 ligand:2x DDX58:2xATP [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:918186] TRIM25 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:918186] TRIM25 [cytosol] [Homo sapiens] [Complex:194364] YWHAE dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9733677] The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity
name	YWHAE binds DDX58 and TRIM25
output	[Complex:9733682] 2xviral dsRNA:2xK63polyUb-DDX58:2xTRIM25:2xATP [cytosol] [Homo sapiens]
precedingEvent	[Reaction:168935] viral dsRNA binds DDX58 [Homo sapiens] [BlackBoxEvent:1964482] RNA polymerase III transcribes microbial dsDNA to dsRNA [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9733683] R-HSA-9733680.1
summation	[Summation:9733678] Upon viral infection, antiviral innate immune response recep...
(hasEvent)	[Pathway:9717624] Regulators of DDX58/IFIH1 signaling [Homo sapiens]
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No pathways have been reviewed or authored by YWHAE binds DDX58 and TRIM25 (9733680)