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Details on Person Viral Spike Binds to ACE2 on Uninfected Cell

Class:Id	Reaction:9733495
_displayName	Viral Spike Binds to ACE2 on Uninfected Cell
_doRelease	TRUE
_timestamp	2022-08-18 10:44:02
authored	[InstanceEdit:9815534] Stephan, Ralf, 2022-08-18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9733469] Stephan, Ralf, 2021-06-04
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9815534] Stephan, Ralf, 2022-08-18
entityOnOtherCell	[EntityWithAccessionedSequence:9683480] glycosylated-ACE2 [plasma membrane] [Homo sapiens]
input	[EntityWithAccessionedSequence:9683480] glycosylated-ACE2 [plasma membrane] [Homo sapiens] [Complex:9733504] Spike trimer [plasma membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9683520] Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target [LiteratureReference:9733499] Syncytia formation by SARS-CoV-2-infected cells [LiteratureReference:9769807] Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation [LiteratureReference:9733465] SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
modified	[InstanceEdit:9733524] Stephan, Ralf, 2021-06-04 [InstanceEdit:9733885] Stephan, Ralf, 2021-06-11 [InstanceEdit:9733902] Gillespie, Marc E, 2021-06-11 [InstanceEdit:9763987] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9769785] Stephan, Ralf, 2022-03-22 [InstanceEdit:9769813] Stephan, Ralf, 2022-03-22 [InstanceEdit:9769951] Stephan, Ralf, 2022-03-23 [InstanceEdit:9770061] Stephan, Ralf, 2022-03-24 [InstanceEdit:9770068] Stephan, Ralf, 2022-03-24 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9796131] Stephan, Ralf, 2022-08-05 [InstanceEdit:9815534] Stephan, Ralf, 2022-08-18 [InstanceEdit:9815539] Stephan, Ralf, 2022-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Viral Spike Binds to ACE2 on Uninfected Cell
negativePrecedingEvent	[NegativePrecedingEvent:9763986] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
output	[Complex:9770060] Spike trimer:ACE2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9769812] Spike Trimer Translocates to the Plasma Membrane [Homo sapiens] [BlackBoxEvent:9694780] Spike translocates to ERGIC [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-09-14
reviewed	[InstanceEdit:9773891] Gillespie, Marc E, 2022-05-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9733522] R-HSA-9733495.2
summation	[Summation:9770069] Excess SARS-CoV-2 spike protein accumulates in the plasma me...
(hasEvent)	[Pathway:9733458] Induction of Cell-Cell Fusion [Homo sapiens]
(precedingEvent)	[Reaction:9769949] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage [Homo sapiens]
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No pathways have been reviewed or authored by Viral Spike Binds to ACE2 on Uninfected Cell (9733495)