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Details on Person May, Bruce, 2021-06-03
| Class:Id | InstanceEdit:9733353 |
| _displayName | May, Bruce, 2021-06-03 |
| _timestamp | 2021-06-03 19:42:44 |
| author | [Person:203835] May, Bruce |
| dateTime | 2021-06-03 19:42:42 |
| (modified) | [Reaction:389159] CSF1R trans-autophosphorylates on multiple tyrosine and serine residues [Homo sapiens] [BlackBoxEvent:9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated [Homo sapiens] [Pathway:9680350] Signaling by CSF1 (M-CSF) in myeloid cells [Homo sapiens] [Complex:9680374] CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] [Homo sapiens] [Reaction:9680385] CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS [Homo sapiens] [CatalystActivity:9680390] guanyl-nucleotide exchange factor activity of CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] |
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No pathways have been reviewed or authored by May, Bruce, 2021-06-03 (9733353)