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Details on Person p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL

Class:Id	BlackBoxEvent:9733316
_displayName	p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL
_doRelease	TRUE
_timestamp	2022-10-09 06:47:58
authored	[InstanceEdit:9733318] May, Bruce, 2021-05-25
catalystActivity	[CatalystActivity:9763902] ubiquitin protein ligase activity of CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9733322] May, Bruce, 2021-06-03
edited	[InstanceEdit:9733318] May, Bruce, 2021-05-25
inferredFrom	[BlackBoxEvent:9763892] p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12 [Mus musculus]
input	[Complex:9733315] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9763923] May, Bruce, 2022-02-07 [InstanceEdit:9766337] May, Bruce, 2022-02-18 [InstanceEdit:9818020] May, Bruce, 2022-10-08 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL
output	[Complex:9733319] CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9733323] Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL [Homo sapiens] [Reaction:9817983] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL [Homo sapiens]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9733346] R-HSA-9733316.2
summation	[Summation:9766323] After CBL is phosphorylated and binds CSF1R, CBL autopolyubi...
(hasEvent)	[Pathway:9680350] Signaling by CSF1 (M-CSF) in myeloid cells [Homo sapiens]
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