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Details on Person COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4

Class:Id	BlackBoxEvent:9733216
_displayName	COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4
_doRelease	TRUE
_timestamp	2022-05-12 22:00:00
authored	[InstanceEdit:9733215] Orlic-Milacic, Marija, 2021-06-01
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9733215] Orlic-Milacic, Marija, 2021-06-01
edited	[InstanceEdit:9773649] Orlic-Milacic, Marija, 2022-05-09
input	[EntityWithAccessionedSequence:6789344] COL1A2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9733230] Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3 [LiteratureReference:9733228] Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma [LiteratureReference:9733222] Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects [LiteratureReference:9733236] Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis [LiteratureReference:9733245] Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts [LiteratureReference:9737487] Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription
modified	[InstanceEdit:9734552] Orlic-Milacic, Marija, 2021-06-17 [InstanceEdit:9737489] Orlic-Milacic, Marija, 2021-07-19 [InstanceEdit:9737496] Orlic-Milacic, Marija, 2021-07-19 [InstanceEdit:9754438] Orlic-Milacic, Marija, 2021-09-24 [InstanceEdit:9773239] Orlic-Milacic, Marija, 2022-05-04 [InstanceEdit:9773673] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773773] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9774071] Orlic-Milacic, Marija, 2022-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4
output	[EntityWithAccessionedSequence:1980213] COL1A2(23-1366) [endoplasmic reticulum lumen] [Homo sapiens]
precedingEvent	[Reaction:9733207] p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter [Homo sapiens] [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens] [Reaction:9733247] YBX1 binds COL1A2 gene promoter [Homo sapiens] [BlackBoxEvent:9736836] Phosphorylated YBX1 translocates to the nucleus [Homo sapiens] [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9733214] Positive gene expression regulation by 'p-2S-SMAD3:p-2S-SMAD3:SMAD4:SP1:EP300:COL1A2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9736833] Negative gene expression regulation by 'p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm]'
releaseDate	2022-06-09
reviewed	[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9733217] R-HSA-9733216.2
summation	[Summation:9737494] Binding of the heterotrimer composed of SMAD4 and two molecu...
(hasEvent)	[Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[Reaction:1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines [Homo sapiens] [Reaction:2002460] P4HB binds Collagen chains [Homo sapiens] [Reaction:8944214] Association of procollagen type I [Homo sapiens]
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No pathways have been reviewed or authored by COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (9733216)