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Details on Person RAF1, activated downstream of IFNG (interferon-gamma) in a J...
| Class:Id | Summation:9732761 |
|---|---|
| _displayName | RAF1, activated downstream of IFNG (interferon-gamma) in a J... |
| _timestamp | 2021-09-07 19:01:22 |
| created | [InstanceEdit:9732760] Orlic-Milacic, Marija, 2021-05-31 |
| literatureReference | [LiteratureReference:9730981] Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway [LiteratureReference:9732728] Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent |
| modified | [InstanceEdit:9753485] Orlic-Milacic, Marija, 2021-09-07 |
| text | RAF1, activated downstream of IFNG (interferon-gamma) in a JAK1-dependent and RAS-independent manner, phosphorylates ERKs: MAPK1 (ERK2) and MAPK3 (ERK1) (Sakatsume et al. 1998). IFNG-mediated activation of ERKs may contribute to transient attenuation of TGF-beta signaling through ERK-mediated phosphorylation of SMAD2 and SMAD3, but a long-term effect depends on IFNG-mediated transcription of SMAD7, an inhibitor of TGF-beta signaling (Ulloa et al. 1999). |
| (summation) | [BlackBoxEvent:9732753] JAK1-activated RAF1 phosphorylates MAPKs [Homo sapiens] |
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No pathways have been reviewed or authored by RAF1, activated downstream of IFNG (interferon-gamma) in a J... (9732761)
