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Details on Person nsp10:nsp14 binds to ExoN inhibitors

Class:Id	Reaction:9731708
_displayName	nsp10:nsp14 binds to ExoN inhibitors
_doRelease	TRUE
_timestamp	2025-01-29 08:44:20
authored	[InstanceEdit:9731578] Stephan, Ralf, 2021-05-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9731693] Stephan, Ralf, 2021-05-24
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9731578] Stephan, Ralf, 2021-05-21
input	[Complex:9694688] nsp10:nsp14 [cytosol] [Severe acute respiratory syndrome coronavirus 2] [DefinedSet:9731679] ExoN inhibitors [cytosol]
isChimeric	FALSE
literatureReference	[URL:9731556] https://doi.org/10.1101/2020.08.13.248211 [LiteratureReference:9762576] New targets for drug design: importance of nsp14/nsp10 complex formation for the 3'-5' exoribonucleolytic activity on SARS-CoV-2 [LiteratureReference:9731676] Raltegravir: the first HIV type 1 integrase inhibitor [LiteratureReference:9731684] Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2 [LiteratureReference:9731677] Structure of M^pro from SARS-CoV-2 and discovery of its inhibitors
modified	[InstanceEdit:9762581] Stephan, Ralf, 2022-01-27 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9773794] Gillespie, Marc E, 2022-05-10 [InstanceEdit:9815360] Stephan, Ralf, 2022-08-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9937067] Stephan, Ralf, 2025-01-29
name	nsp10:nsp14 binds to ExoN inhibitors
output	[Complex:9815359] ExoN inhibitors:nsp10:nsp14 [cytosol] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[Reaction:9694542] nsp14 binds nsp10 [Homo sapiens] [Reaction:9694551] 3CLp cleaves nsp6-11 [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9731718] R-HSA-9731708.4
summation	[Summation:9731709] Nsp14:nsp10 (ExoN) is a highly versatile nuclease capable of...
(hasEvent)	[Pathway:9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9847081] Update Tracker - [Reaction:9731708] nsp10:nsp14 binds to ExoN inhibitors - v82:[add_removeOutput]
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No pathways have been reviewed or authored by nsp10:nsp14 binds to ExoN inhibitors (9731708)