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Details on Person NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP

Class:IdReaction:9731613
_displayNameNUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP
_doReleaseTRUE
_timestamp2025-12-10 22:49:53
authored[InstanceEdit:9731600] D'Eustachio, Peter, 2021-05-21
catalystActivity[CatalystActivity:9731616] hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides of NUDT1 [cytosol]
catalystActivityReference[CatalystActivityReference:9731593] hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides of NUDT1 [cytosol] MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
compartment[Compartment:70101] cytosol
created[InstanceEdit:9731615] D'Eustachio, Peter, 2021-05-21
crossReference[DatabaseIdentifier:9976356] RHEA:67605
edited[InstanceEdit:9731600] D'Eustachio, Peter, 2021-05-21
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:9731628] N(6)-methyl-dATP(4-) [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1418849] Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria
[LiteratureReference:2395806] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
[LiteratureReference:2395856] Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism
[LiteratureReference:2395831] Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
[LiteratureReference:9731608] MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
[LiteratureReference:2394017] Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2
modified[InstanceEdit:9731624] D'Eustachio, Peter, 2021-05-21
[InstanceEdit:9731633] D'Eustachio, Peter, 2021-05-21
[InstanceEdit:9731937] D'Eustachio, Peter, 2021-05-25
[InstanceEdit:9748645] D'Eustachio, Peter, 2021-07-23
[InstanceEdit:9751177] D'Eustachio, Peter, 2021-08-18
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
nameNUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP
N(6)-methyl-dATP + H2O => N(6)-methyl-dAMP + diphosphate + H(+)
output[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:9731609] N(6)-methyl-dAMP(2-) [cytosol]
[SimpleEntity:111294] PPi [cytosol]
releaseDate2021-09-15
reviewed[InstanceEdit:9731938] Jassal, Bijay, 2021-05-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9731620] R-HSA-9731613.3
summation[Summation:9731596] NUDT1 (MTH1) catalyzes the reaction of N6-methyl-dATP and wa...
(hasEvent)[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(precedingEvent)[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens]
[Reaction:9731661] MAPDA hydrolyzes N6-methyl-dAMP to dIMP and methylamine [Homo sapiens]
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