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Details on Person Inhibitor of nuclear factor kappa-B kinase subunit epsilon (...
| Class:Id | Summation:9731433 |
|---|---|
| _displayName | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (... |
| _timestamp | 2021-05-20 21:22:47 |
| created | [InstanceEdit:9731427] Shamovsky, Veronica, 2021-05-20 |
| literatureReference | [LiteratureReference:9705328] IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex [LiteratureReference:9731432] Advances in IKBKE as a potential target for cancer therapy [LiteratureReference:9731426] Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer |
| text | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE or IKKi) undergoes K63-linked polyubiquitination in mouse and human cells (Zhou AY et al. 2013). This modification promotes IKBKE kinase activity in mouse macrophage-like cells (RAW 264.7) in response to inflammatory stimuli such as lipopolysaccharide (LPS). It also induced the IKBKE activity in human breast cancer cell lines (MCF-7 and ZR-75-1) (Zhou AY et al. 2013) that express high levels of IKBKE protein (reviewed in Durand JK et al. 2018; Yin M et al. 2020). Mutagenesis studies revealed that IKBKE is ubiquitinated at K30 and K401 (Zhou AY et al. 2013). E3 ligase complex, composed of TNFR-associated factor 2 (TRAF2) and cellular inhibitor of apoptosis (BIRC2, BIRC3 also known as cIAP1, cIAP2), was found to bind to and ubiquitinate IKBKE promoting activation of IKBKE (Zhou AY et al. 2013). These data suggest that the K63-linked polyubiquitination of IKBKE at K30 and K401 is required for IKBKE activity in both inflammatory and oncogenic contexts. |
| (summation) | [BlackBoxEvent:9730433] K63-linked polyubiquitination of IKBKE by BIRC2,3:TRAF2 [Homo sapiens] |
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No pathways have been reviewed or authored by Inhibitor of nuclear factor kappa-B kinase subunit epsilon (... (9731433)
