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Details on Person EDNRA, EDNRB bind non-selective ERAs

Class:Id	Reaction:9731393
_displayName	EDNRA, EDNRB bind non-selective ERAs
_doRelease	TRUE
_timestamp	2022-05-10 17:55:50
authored	[InstanceEdit:9731395] Jassal, Bijay, 2021-05-20
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9731395] Jassal, Bijay, 2021-05-20
definition	Antagonist
edited	[InstanceEdit:9731395] Jassal, Bijay, 2021-05-20 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input	[DefinedSet:9731346] non-selective ERAs [extracellular region] [DefinedSet:388547] EDNRA,EDNRB [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9731877] Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist [LiteratureReference:9731907] Pharmacokinetic-pharmacodynamic relationships of macitentan, a new endothelin receptor antagonist, after multiple dosing in healthy Korean subjects [LiteratureReference:9731881] Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects
modified	[InstanceEdit:9731421] Jassal, Bijay, 2021-05-20 [InstanceEdit:9731895] Jassal, Bijay, 2021-05-25 [InstanceEdit:9731928] Jassal, Bijay, 2021-05-25 [InstanceEdit:9773229] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10 [InstanceEdit:9773858] Matthews, Lisa, 2022-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EDNRA, EDNRB bind non-selective ERAs EDNRA, EDNRB bind EDNR antagonists
output	[Complex:9731404] EDNRA,EDNRB:non-selective ERAs [plasma membrane] [Homo sapiens]
reactionType	[DrugActionType:9725064] Antagonist
releaseDate	2022-06-09
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9731419] R-HSA-9731393.2
summation	[Summation:9731914] Endothelins (EDNs) are 21-amino acid vasoconstricting peptid...
(hasEvent)	[Pathway:375276] Peptide ligand-binding receptors [Homo sapiens]
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No pathways have been reviewed or authored by EDNRA, EDNRB bind non-selective ERAs (9731393)