Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP

Class:Id	Reaction:9731228
_displayName	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP
_doRelease	TRUE
_timestamp	2025-12-10 22:49:51
authored	[InstanceEdit:9731236] D'Eustachio, Peter, 2021-05-18
catalystActivity	[CatalystActivity:9731237] 8-oxo-(d)RTP hydrolase activity of NUDT1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9731238] 8-oxo-(d)RTP hydrolase activity of NUDT1 [cytosol] Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9731239] D'Eustachio, Peter, 2021-05-18
crossReference	[DatabaseIdentifier:9976330] RHEA:65397
edited	[InstanceEdit:9731236] D'Eustachio, Peter, 2021-05-18
input	[SimpleEntity:9731229] 8-oxo-dATP(4-) [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2395814] The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein [LiteratureReference:1418849] Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria [LiteratureReference:2395806] Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates [LiteratureReference:2395856] Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism [LiteratureReference:2395820] An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
modified	[InstanceEdit:9731252] D'Eustachio, Peter, 2021-05-18 [InstanceEdit:9731289] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731341] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731342] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731343] D'Eustachio, Peter, 2021-05-19 [InstanceEdit:9731940] D'Eustachio, Peter, 2021-05-25 [InstanceEdit:9748645] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9751177] D'Eustachio, Peter, 2021-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP 8-oxo-dATP + H2O => 8-oxo-dAMP + diphosphate + H(+)
output	[SimpleEntity:9731235] 8-oxo-dAMP(2-) [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2021-09-15
reviewed	[InstanceEdit:9731938] Jassal, Bijay, 2021-05-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9731248] R-HSA-9731228.3
summation	[Summation:9731230] NUDT1 (MTH1) catalyzes the reaction of 8-oxo-dATP and water ...
(hasEvent)	[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (9731228)