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Details on Person Alkylating chemotherapeutic drugs from the triazene group, d...

Class:IdSummation:9730764
_displayNameAlkylating chemotherapeutic drugs from the triazene group, d...
_timestamp2021-08-09 20:35:09
created[InstanceEdit:9730765] Orlic-Milacic, Marija, 2021-05-11
literatureReference[LiteratureReference:9730876] DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine
[LiteratureReference:9616000] Balancing repair and tolerance of DNA damage caused by alkylating agents
[LiteratureReference:9730897] Alkylation of DNA in rat tissues following administration of streptozotocin
modified[InstanceEdit:9730776] Orlic-Milacic, Marija, 2021-05-11
[InstanceEdit:9730888] Orlic-Milacic, Marija, 2021-05-11
[InstanceEdit:9730895] Orlic-Milacic, Marija, 2021-05-11
[InstanceEdit:9730909] Orlic-Milacic, Marija, 2021-05-11
[InstanceEdit:9730910] Orlic-Milacic, Marija, 2021-05-11
[InstanceEdit:9730918] Orlic-Milacic, Marija, 2021-05-11
[InstanceEdit:9736386] Orlic-Milacic, Marija, 2021-07-07
[InstanceEdit:9736588] Orlic-Milacic, Marija, 2021-07-13
[InstanceEdit:9749815] Orlic-Milacic, Marija, 2021-08-05
[InstanceEdit:9749874] Orlic-Milacic, Marija, 2021-08-06
[InstanceEdit:9750139] Orlic-Milacic, Marija, 2021-08-09
textAlkylating chemotherapeutic drugs from the triazene group, dacarbazine (van Delft 1992), procarbazine (Wiestler et al. 1984 - study done in rats), temozolomide (Plummer et al. 2005), and streptozocin (streptozotocin) (Bennett and Pegg 1981 - study done in rats), produce N7-methylguanine adducts on double-stranded DNA (7meG-dsDNA). 7-methylguanine is the predominant methylation adduct produced by monofunctional alkylating chemotherapeutics, accounting for 60-80% of total alkylating lesions in DNA (reviewed by Fu et al. 2012).
(summation)[BlackBoxEvent:9730767] Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA [Homo sapiens]
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