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Details on Person Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA

Class:Id	BlackBoxEvent:9730736
_displayName	Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA
_doRelease	TRUE
_timestamp	2021-08-06 18:30:45
authored	[InstanceEdit:9730922] Orlic-Milacic, Marija, 2021-05-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9730735] Orlic-Milacic, Marija, 2021-05-10
edited	[InstanceEdit:9749854] Orlic-Milacic, Marija, 2021-08-06
inferredFrom	[BlackBoxEvent:9730898] Streptozocin (streptozotocin) produces 3-methyladenine in dsDNA [Rattus norvegicus]
input	[GenomeEncodedEntity:5649637] dsDNA [nucleoplasm] [Homo sapiens] [CandidateSet:9730920] dacarbazine,streptozocin,temozolomide,(procarbazine) [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9730866] Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen [LiteratureReference:9730894] Antitumour imidazotetrazines XXVIII 3-methyladenine DNA glycosylase activity in cell lines sensitive and resistant to temozolomide
modified	[InstanceEdit:9730863] Orlic-Milacic, Marija, 2021-05-11 [InstanceEdit:9730874] Orlic-Milacic, Marija, 2021-05-11 [InstanceEdit:9730895] Orlic-Milacic, Marija, 2021-05-11 [InstanceEdit:9730904] Orlic-Milacic, Marija, 2021-05-11 [InstanceEdit:9730922] Orlic-Milacic, Marija, 2021-05-11 [InstanceEdit:9749860] Orlic-Milacic, Marija, 2021-08-06 [InstanceEdit:9749875] Orlic-Milacic, Marija, 2021-08-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA
output	[GenomeEncodedEntity:110201] 3meA-dsDNA [nucleoplasm] [Homo sapiens]
releaseDate	2021-09-15
reviewed	[InstanceEdit:9749858] Kadambat Nair, Sisira, 2021-07-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9730738] R-HSA-9730736.2
summation	[Summation:9730734] Alkylating chemotherapeutic drugs from the triazene group, d...
(hasEvent)	[Pathway:9730737] Alkylating DNA damage induced by chemotherapeutic drugs [Homo sapiens]
(precedingEvent)	[Reaction:110238] MPG glycosylase mediated recognition and binding of 3-methyladenine [Homo sapiens]
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No pathways have been reviewed or authored by Monofunctional chemotherapeutic alkylating drugs produce 3-methyladenine in dsDNA (9730736)