Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Upon SARS-CoV-2 infection a strong global decrease in steady...
| Class:Id | Summation:9730485 |
|---|---|
| _displayName | Upon SARS-CoV-2 infection a strong global decrease in steady... |
| _timestamp | 2022-02-17 05:14:34 |
| created | [InstanceEdit:9730489] Stephan, Ralf, 2021-05-07 |
| modified | [InstanceEdit:9755983] Shamovsky, Veronica, 2021-10-12 [InstanceEdit:9765915] Shamovsky, Veronica, 2022-02-17 |
| text | Upon SARS-CoV-2 infection a strong global decrease in steady-state mRNA levels (relative to ncRNA levels) is observed. Many of the key genes stimulated by IFN are spliced, and an increase in intron retention in multiple IFN-responsive genes (such as ISG15 and RIG-I) is seen in infected human lung epithelial cells (Calu3). SARS-CoV-2 nonstructural protein 16 (nsp16), besides its role in viral RNA cap modification, binds to the 5′ splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome, disrupting global mRNA splicing (Banerjee et al, 2020). |
| (summation) | [Reaction:9730488] SARS-CoV-2 nsp16 binds to U2 snRNA [Homo sapiens] |
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No pathways have been reviewed or authored by Upon SARS-CoV-2 infection a strong global decrease in steady... (9730485)
