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Details on Person Latent TGF-beta-3 is cleaved by FURIN

Class:Id	Reaction:9729941
_displayName	Latent TGF-beta-3 is cleaved by FURIN
_doRelease	FALSE
_timestamp	2021-07-19 16:50:07
catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:9729938] Orlic-Milacic, Marija, 2021-05-04
inferredFrom	[Reaction:170844] Latent TGF-beta-1 is cleaved by FURIN [Homo sapiens] [Reaction:9729936] Latent TGF-beta-2 is cleaved by FURIN [Homo sapiens]
input	[Complex:9729942] Pre-TGFB3 complex [Golgi lumen] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9729950] Orlic-Milacic, Marija, 2021-05-04 [InstanceEdit:9729964] Orlic-Milacic, Marija, 2021-05-04 [InstanceEdit:9737411] Orlic-Milacic, Marija, 2021-07-19
name	Latent TGF-beta-3 is cleaved by FURIN
output	[Complex:9729952] TGF-beta-3:LAP3 [Golgi lumen] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9729948] R-HSA-9729941.1
summation	[Summation:9737410] Cleavage of TGFB3 precursor by FURIN protease has not been e...
(hasEvent)	[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens] [Pathway:9753549] TGF-beta ligand biogenesis, secretion and activation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9736810] Secretion and activation of the latent large complex of TGF-beta-3 [Homo sapiens]
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No pathways have been reviewed or authored by Latent TGF-beta-3 is cleaved by FURIN (9729941)