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Details on Person SARS-CoV-2 nsp1 binds to 40S ribosomal complex
Class:Id Reaction:9729849 _displayName SARS-CoV-2 nsp1 binds to 40S ribosomal complex _doRelease TRUE _timestamp 2023-01-24 21:38:42 authored [InstanceEdit:9729750] Stephan, Ralf, 2021-05-03 compartment [Compartment:70101] cytosol created [InstanceEdit:9729799] Stephan, Ralf, 2021-05-03 disease [Disease:9683912] COVID-19 edited [InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18 input [Complex:72392] 40S ribosomal complex [cytosol] [Homo sapiens] [DefinedSet:9694741] nsp1 [cytosol] [Severe acute respiratory syndrome coronavirus 2] isChimeric FALSE literatureReference [LiteratureReference:9729230] A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein [LiteratureReference:9729826] SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation [LiteratureReference:9729794] Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 [LiteratureReference:9729781] SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses [LiteratureReference:9729828] Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA [LiteratureReference:9729815] The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation [LiteratureReference:9729813] Genes with 5' terminal oligopyrimidine tracts preferentially escape global suppression of translation by the SARS-CoV-2 NSP1 protein [LiteratureReference:9729834] SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism [LiteratureReference:9762482] Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2 [LiteratureReference:9762483] SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block [LiteratureReference:9825259] Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation [LiteratureReference:9825268] Structural insights into the activity regulation of full-length non-structural protein 1 from SARS-CoV-2 [LiteratureReference:9825267] The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression modified [InstanceEdit:9731325] Stephan, Ralf, 2021-05-19 [InstanceEdit:9762469] Stephan, Ralf, 2022-01-25 [InstanceEdit:9766202] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766343] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767652] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9825264] Shamovsky, Veronica, 2023-01-24 [InstanceEdit:9825270] Shamovsky, Veronica, 2023-01-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name SARS-CoV-2 nsp1 binds to 40S ribosomal complex output [Complex:9729832] 40S ribosomal complex:nsp1 [cytosol] [Homo sapiens] precedingEvent
relatedSpecies [Species:9681683] Severe acute respiratory syndrome coronavirus 2 releaseDate 2022-03-23 reviewed [InstanceEdit:9766195] Messina, Francesco, 2022-02-18 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9729861] R-HSA-9729849.3 summation [Summation:9729821] SARS-CoV-1 nsp1 induces a near-complete shutdown of host pro... (hasEvent) [Pathway:9754678] SARS-CoV-2 modulates host translation machinery [Homo sapiens] (updatedInstance) [_UpdateTracker:9846596] Update Tracker - [Reaction:9729849] SARS-CoV-2 nsp1 binds to 40S ribosomal complex - v84:[addLiteratureReference, modifyText]
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