Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person SARS-CoV-2 3CLpro dimer cleaves NLRP12

Class:Id	Reaction:9729741
_displayName	SARS-CoV-2 3CLpro dimer cleaves NLRP12
_doRelease	TRUE
_timestamp	2022-03-01 03:11:07
authored	[InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
catalystActivity	[CatalystActivity:9694394] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
input	[EntityWithAccessionedSequence:561195] NLRP12 [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9729719] SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species [LiteratureReference:9729717] PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing [LiteratureReference:9729710] Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes
modified	[InstanceEdit:9756480] Shamovsky, Veronica, 2021-10-14 [InstanceEdit:9766202] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766342] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767633] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 3CLpro dimer cleaves NLRP12
output	[EntityWithAccessionedSequence:9729718] NLRP12(1-240) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9729744] NLRP12(1-937) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9729690] NLRP12(241-1061) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9729702] NLRP12(938-1061) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9694333] 3CLp forms a homodimer [Homo sapiens] [Reaction:9694377] pp1a cleaves itself [Homo sapiens] [Reaction:9694441] 3CLp cleaves pp1a [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9729758] R-HSA-9729741.2
summation	[Summation:9729705] SARS-CoV-2 nsp5 protease (3CLpro) specifically cleaves NLRP1...
(hasEvent)	[Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by SARS-CoV-2 3CLpro dimer cleaves NLRP12 (9729741)