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Details on Person SARS-CoV-2 3CLpro dimer cleaves TAB1

Class:Id	Reaction:9729704
_displayName	SARS-CoV-2 3CLpro dimer cleaves TAB1
_doRelease	TRUE
_timestamp	2022-03-01 03:11:25
authored	[InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
catalystActivity	[CatalystActivity:9694394] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729750] Stephan, Ralf, 2021-05-03
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
input	[EntityWithAccessionedSequence:167923] TAB1 [cytosol] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9729719] SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species [LiteratureReference:4332321] TAK1, more than just innate immunity [LiteratureReference:9729746] ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)
modified	[InstanceEdit:9756480] Shamovsky, Veronica, 2021-10-14 [InstanceEdit:9766202] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766342] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767634] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 3CLpro dimer cleaves TAB1
output	[EntityWithAccessionedSequence:9729698] TAB1(1-132) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9729751] TAB1(1-444) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9729724] TAB1(133-504) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9729691] TAB1(445-504) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9694333] 3CLp forms a homodimer [Homo sapiens] [Reaction:9694377] pp1a cleaves itself [Homo sapiens] [Reaction:9694441] 3CLp cleaves pp1a [Homo sapiens] [Reaction:9694732] 3CLp cleaves pp1ab [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9729756] R-HSA-9729704.2
summation	[Summation:9729716] SARS-CoV-2 nsp5 protease (3CLpro) specifically cleaves TAB1 ...
(hasEvent)	[Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-2 3CLpro dimer cleaves TAB1 (9729704)