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Details on Person RNF128 polyubiquitinates TBK1

Class:IdBlackBoxEvent:9729623
_displayNameRNF128 polyubiquitinates TBK1
_doReleaseFALSE
_timestamp2021-11-25 04:11:29
catalystActivity[CatalystActivity:9729612] ubiquitin protein ligase activity of RNF128 [cytosol]
catalystActivityReference[CatalystActivityReference:9729609] ubiquitin protein ligase activity of RNF128 [cytosol] E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1
compartment[Compartment:70101] cytosol
created[InstanceEdit:9729613] Shamovsky, Veronica, 2021-05-03
goBiologicalProcess[GO_BiologicalProcess:260609] positive regulation of interleukin-1 beta production
input[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
[Polymer:450152] K63polyUb [cytosol] [Homo sapiens]
[Complex:9730431] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1 [mitochondrial outer membrane] [Homo sapiens]
[Complex:9730424] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1 [mitochondrial outer membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9729658] E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1
modified[InstanceEdit:9729888] Shamovsky, Veronica, 2021-05-04
[InstanceEdit:9730422] Shamovsky, Veronica, 2021-05-07
[InstanceEdit:9758830] Shamovsky, Veronica, 2021-11-25
nameRNF128 polyubiquitinates TBK1
K63-linked polyubiquitination of TBK1
output[Complex:9730419] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xK63polyUb-TBK1 [mitochondrial outer membrane] [Homo sapiens]
[Complex:9730438] dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xK63polyUb-TBK1 [mitochondrial outer membrane] [Homo sapiens]
relatedSpecies[Species:5621375] Hepatitis C Virus
[Species:5617433] Rotavirus
[Species:9031716] Influenza A virus
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9729661] R-HSA-9729623.1
summation[Summation:9729887] E3 ubiquitin-protein ligase RNF128 co-immunoprecipitates wit...
(hasEvent)[Pathway:9717624] Regulators of DDX58/IFIH1 signaling [Homo sapiens]
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