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Details on Person Stress granules (SGs) are dynamic large cytoplasmic mRNA-pro...
| Class:Id | Summation:9729477 |
|---|---|
| _displayName | Stress granules (SGs) are dynamic large cytoplasmic mRNA-pro... |
| _timestamp | 2022-02-18 04:40:27 |
| created | [InstanceEdit:9729515] Stephan, Ralf, 2021-04-28 |
| literatureReference | [URL:9729496] https://doi.org/10.1101/2020.10.23.342113 [LiteratureReference:9705013] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing [LiteratureReference:9729494] SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production [LiteratureReference:9729506] SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation into stress granules through its N-terminal intrinsically disordered region [LiteratureReference:9755717] Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein |
| modified | [InstanceEdit:9755789] Shamovsky, Veronica, 2021-10-11 [InstanceEdit:9755980] Shamovsky, Veronica, 2021-10-12 [InstanceEdit:9766212] Shamovsky, Veronica, 2022-02-18 |
| text | Stress granules (SGs) are dynamic large cytoplasmic mRNA-protein aggregates, formed in response to various stresses, including heat shock, oxidative stress, or viral infection. They can counter viral infection by insulating invaders and limiting viral mRNA translation. SARS-CoV-2 nucleocapsid (N) protein interacts with the SG core component G3BP1/2 (Nabeel-Shah et al. 2020; Gordon et al. 2020; Luo et al. 2021; Wang et al. 2021) and almost completely disrupts SG formation. GST pull-down assays with wild-type and truncated proteins indicated that a fragment from the N-terminal intrinsically disordered region (N-IDR, aa1–48) of N protein and the nuclear transport factor 2 (NTF2) domain of G3BP1are required for the interaction (Huang W et al. 2021). N protein impaired the interaction between G3BP1 and other SG-related proteins and led to SG reconstitution through phase separating with G3BP to occupy protein–protein interaction positions of G3BP (Huang W et al. 2021). It is proposed that N protein-mediated SG disassembly is crucial for SARS-CoV-2 production (Luo et al. 2021; Wang et al. 2021). |
| (summation) | [Reaction:9729481] SARS-CoV-2 N binds to G3BP1,G3BP2 [Homo sapiens] |
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No pathways have been reviewed or authored by Stress granules (SGs) are dynamic large cytoplasmic mRNA-pro... (9729477)
