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Details on Person CSNK1A1 phosphorylates nucleoprotein
Class:Id Reaction:9729318
_displayName CSNK1A1 phosphorylates nucleoprotein
_doRelease TRUE
_timestamp 2022-04-29 20:03:31
authored [InstanceEdit:9728847] Stephan, Ralf, 2021-04-22
catalystActivity [CatalystActivity:5610635] protein serine/threonine kinase activity of CSNK1A1 [cytosol]
catalystActivityReference [CatalystActivityReference:9729582] protein serine/threonine kinase activity of CSNK1A1 [cytosol] The Global Phosphorylation Landscape of SARS-CoV-2 Infection
compartment [Compartment:70101] cytosol
created [InstanceEdit:9729337] Stephan, Ralf, 2021-04-28
disease [Disease:9683912] COVID-19
edited [InstanceEdit:9730587] Stephan, Ralf, 2021-05-10
input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:9729335] p-8S-N [cytosol] [Severe acute respiratory syndrome coronavirus 2]
isChimeric FALSE
literatureReference [LiteratureReference:9729344] The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro [LiteratureReference:9729331] The Global Phosphorylation Landscape of SARS-CoV-2 Infection [LiteratureReference:9729273] Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein [LiteratureReference:9729276] Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication
modified [InstanceEdit:9729581] Stephan, Ralf, 2021-04-29 [InstanceEdit:9729584] Stephan, Ralf, 2021-04-29 [InstanceEdit:9730583] Stephan, Ralf, 2021-05-10 [InstanceEdit:9730586] Stephan, Ralf, 2021-05-10 [InstanceEdit:9730589] Stephan, Ralf, 2021-05-10 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name CSNK1A1 phosphorylates nucleoprotein Phosphorylation of nucleoprotein
output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [EntityWithAccessionedSequence:9729277] p-8S,2T-N [cytosol] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent
relatedSpecies [Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate 2021-06-09
reviewed [InstanceEdit:9730585] Acencio, Marcio Luis, 2021-05-09
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9729355] R-HSA-9729318.3
summation [Summation:9729333] SARS-Cov-2 nucleoprotein is phosphorylated by several host c...
(hasEvent) [Pathway:9694631] Maturation of nucleoprotein [Homo sapiens]
(precedingEvent) [Reaction:9729283] Nucleoprotein is methylated by PRMT1 [Homo sapiens] [Reaction:9729300] Unknown kinase phosphorylates nucleoprotein [Homo sapiens]
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