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Details on Person GSK3 phosphorylates nucleoprotein

Class:Id	Reaction:9729260
_displayName	GSK3 phosphorylates nucleoprotein
_doRelease	TRUE
_timestamp	2022-04-29 20:03:50
authored	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28
catalystActivity	[CatalystActivity:5661486] protein serine/threonine kinase activity of GSK3 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729337] Stephan, Ralf, 2021-04-28
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9698836] Stephan, Ralf, 2020-08-28 [InstanceEdit:9730583] Stephan, Ralf, 2021-05-10
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:9729324] p-S188,206-N [cytosol] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9713210] Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein [LiteratureReference:9729344] The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro [LiteratureReference:9729331] The Global Phosphorylation Landscape of SARS-CoV-2 Infection [LiteratureReference:9729273] Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein [LiteratureReference:9729276] Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication [LiteratureReference:9762453] Variable posttranslational modifications of severe acute respiratory syndrome coronavirus 2 nucleocapsid protein
modified	[InstanceEdit:9729580] Stephan, Ralf, 2021-04-29 [InstanceEdit:9730583] Stephan, Ralf, 2021-05-10 [InstanceEdit:9730586] Stephan, Ralf, 2021-05-10 [InstanceEdit:9730940] Stephan, Ralf, 2021-05-12 [InstanceEdit:9762455] Stephan, Ralf, 2022-01-25 [InstanceEdit:9773094] Gillespie, Marc E, 2022-04-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GSK3 phosphorylates nucleoprotein Phosphorylation of nucleoprotein
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [EntityWithAccessionedSequence:9729335] p-8S-N [cytosol] [Severe acute respiratory syndrome coronavirus 2]
precedingEvent	[Reaction:9729330] SRPK1/2 phosphorylates nucleoprotein [Homo sapiens] [BlackBoxEvent:9683735] mRNA9 is translated to Nucleoprotein [Homo sapiens] [BlackBoxEvent:9694370] mRNA9a is translated to Nucleoprotein [Homo sapiens]
regulatedBy	[NegativeRegulation:9687655] Negative regulation by 'GSK3B:GSKi [cytosol]'
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2021-06-09
reviewed	[InstanceEdit:9699044] Acencio, Marcio Luis, 2020-09-09 [InstanceEdit:9730585] Acencio, Marcio Luis, 2021-05-09
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9730582] Stephan, Ralf, 2021-05-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9729358] R-HSA-9729260.4
summation	[Summation:9694680] Phosphorylation of SARS-Cov-2 nucleocapsid is catalyzed by g...
(hasEvent)	[Pathway:9694631] Maturation of nucleoprotein [Homo sapiens]
(precedingEvent)	[Reaction:9729318] CSNK1A1 phosphorylates nucleoprotein [Homo sapiens]
(replacementInstances)	[_Deleted:9728923] Deletion of instance: 9694620 [_Deleted:9730588] Deletion of instance: 9694293
(updatedInstance)	[_UpdateTracker:9775259] Update Tracker - [Reaction:9729260] GSK3 phosphorylates nucleoprotein - v80:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by GSK3 phosphorylates nucleoprotein (9729260)