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Details on Person SARS-CoV-1 nsp1 binds to 40S ribosomal subunit

Class:Id	Reaction:9729232
_displayName	SARS-CoV-1 nsp1 binds to 40S ribosomal subunit
_doRelease	TRUE
_timestamp	2022-08-18 02:49:35
authored	[InstanceEdit:9729223] Stephan, Ralf, 2021-04-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9729224] Stephan, Ralf, 2021-04-25
disease	[Disease:9678120] severe acute respiratory syndrome
edited	[InstanceEdit:9815358] Stephan, Ralf, 2022-08-17
input	[Complex:72392] 40S ribosomal complex [cytosol] [Homo sapiens] [DefinedSet:9682210] nsp1 [cytosol] [Human SARS coronavirus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9729230] A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein [LiteratureReference:9729226] Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression [LiteratureReference:9728829] Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation [LiteratureReference:9729235] Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation [LiteratureReference:9729225] SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage [LiteratureReference:9729231] Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA
modified	[InstanceEdit:9736370] Shamovsky, Veronica, 2021-07-07 [InstanceEdit:9796177] Shamovsky, Veronica, 2022-08-05 [InstanceEdit:9796657] Shamovsky, Veronica, 2022-08-11 [InstanceEdit:9815486] Shamovsky, Veronica, 2022-08-18 [InstanceEdit:9815495] Shamovsky, Veronica, 2022-08-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-1 nsp1 binds to 40S ribosomal subunit
output	[Complex:9729228] 40S ribosomal complex:nsp1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9684336] nsp1-4 cleaves itself [Homo sapiens] [Reaction:9684273] 3CLp cleaves pp1a [Homo sapiens] [Reaction:9684340] 3CLp cleaves pp1ab [Homo sapiens]
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2022-09-14
reviewed	[InstanceEdit:9713569] D'Eustachio, Peter, 2021-01-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9729238] R-HSA-9729232.2
summation	[Summation:9729222] In expression studies, SARS-CoV-1 nonstructural protein (nsp...
(hasEvent)	[Pathway:9735869] SARS-CoV-1 modulates host translation machinery [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (9729232)