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Details on Person Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex

Class:Id	Reaction:9727502
_displayName	Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex
_doRelease	TRUE
_timestamp	2024-05-24 11:37:36
authored	[InstanceEdit:9727487] May, Bruce, 2021-04-15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9727501] May, Bruce, 2021-04-16
edited	[InstanceEdit:9727487] May, Bruce, 2021-04-15
input	[EntityWithAccessionedSequence:4655420] Dnmt3a [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5334127] Dnmt3l [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9727508] Spocd1 [nucleoplasm] [Mus musculus] [Complex:5606262] MeR-Piwil4:2'-O-methyl-piRNA [nucleoplasm] [Mus musculus] [OtherEntity:72084] nascent pre-mRNA transcript [nucleoplasm] [Complex:5096465] mNuRD complex [nucleoplasm] [Mus musculus] [Complex:9727478] BAF complex [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9909711] Gm52993 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9909815] Dnmt3c [nucleoplasm] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9727505] SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation [LiteratureReference:9909708] C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
modified	[InstanceEdit:9731674] May, Bruce, 2021-05-22 [InstanceEdit:9909823] May, Bruce, 2024-05-14 [InstanceEdit:9910929] Matthews, Lisa, 2024-05-24
name	Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex
output	[Complex:9727443] nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd1:Dnmt3a:Dnmt3l [nucleoplasm] [Mus musculus]
releaseDate	2024-06-15
reviewed	[InstanceEdit:9910930] Bourc'his, Deborah, 2024-05-24 [InstanceEdit:9910931] Fernandes, Liane P, 2024-05-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9727518] R-MMU-9727502.1
structureModified	[InstanceEdit:9909823] May, Bruce, 2024-05-14
summation	[Summation:9731672] In mouse fetal gonocytes undergoing de novo DNA methylation,...
(inferredFrom)	[Reaction:9727450] PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex [Homo sapiens]
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No pathways have been reviewed or authored by Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex (9727502)