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Details on Person Neprilysin (MME, neutral endopeptidase NEP) is the major enz...
| Class:Id | Summation:9727389 |
|---|---|
| _displayName | Neprilysin (MME, neutral endopeptidase NEP) is the major enz... |
| _timestamp | 2021-04-19 08:31:47 |
| created | [InstanceEdit:9727399] Jassal, Bijay, 2021-04-16 |
| modified | [InstanceEdit:9727564] Jassal, Bijay, 2021-04-19 |
| text | Neprilysin (MME, neutral endopeptidase NEP) is the major enzyme involved in the metabolic inactivation of a number of bioactive signaling peptides including the enkephalins, substance P, endothelin, bradykinin, atrial natriuretic factor (NPPA), and the incretin hormone glucagon-like peptide 1. MME requires zinc as cofactor (Oefner et al. 2004, Oefner et al. 2007). Here, MME is shown to hydrolyse NPPA, inactivating it (Yandle et al. 1989, Vanneste et al. 1988). |
| (summation) | [Reaction:9727387] MME:Zn2+ hydrolyses NPPA [Homo sapiens] |
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No pathways have been reviewed or authored by Neprilysin (MME, neutral endopeptidase NEP) is the major enz... (9727389)
