Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis

Class:IdCellDevelopmentStep:9727359
_displayNameKeratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis
_doReleaseTRUE
_timestamp2024-05-23 14:18:23
authored[InstanceEdit:9839035] Orlic-Milacic, Marija, 2023-06-29
compartment[Compartment:984] extracellular region
created[InstanceEdit:9727356] Orlic-Milacic, Marija, 2021-04-16
edited[InstanceEdit:9863489] Orlic-Milacic, Marija, 2024-02-29
goBiologicalProcess[GO_BiologicalProcess:528093] keratinocyte development
input[Cell:9727360] keratinocyte of spinosum layer of epidermis [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9727647] Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C
[LiteratureReference:9727651] Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function
[LiteratureReference:9727663] Expression of loricrin is negatively controlled by retinoic acid in human epidermis reconstructed in vitro
[LiteratureReference:9727657] Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid
[LiteratureReference:9839000] Mitotic Diversity in Homeostatic Human Interfollicular Epidermis
[LiteratureReference:9839484] PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data
[LiteratureReference:9820674] CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data
[LiteratureReference:9861244] Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin, cultured keratinocytes, and reconstituted epidermis, using large DNA microarrays
[LiteratureReference:9840019] Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution
[LiteratureReference:9861113] Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment
modified[InstanceEdit:9727649] Orlic-Milacic, Marija, 2021-04-19
[InstanceEdit:9727655] Orlic-Milacic, Marija, 2021-04-19
[InstanceEdit:9727665] Orlic-Milacic, Marija, 2021-04-19
[InstanceEdit:9832789] Orlic-Milacic, Marija, 2023-04-09
[InstanceEdit:9833485] Orlic-Milacic, Marija, 2023-04-27
[InstanceEdit:9836316] Orlic-Milacic, Marija, 2023-05-25
[InstanceEdit:9839005] Orlic-Milacic, Marija, 2023-06-28
[InstanceEdit:9839178] Orlic-Milacic, Marija, 2023-07-01
[InstanceEdit:9839182] Orlic-Milacic, Marija, 2023-07-01
[InstanceEdit:9839717] Orlic-Milacic, Marija, 2023-07-07
[InstanceEdit:9841888] Orlic-Milacic, Marija, 2023-08-15
[InstanceEdit:9844372] Orlic-Milacic, Marija, 2023-09-15
[InstanceEdit:9851190] Orlic-Milacic, Marija, 2023-10-13
[InstanceEdit:9852746] Orlic-Milacic, Marija, 2023-11-06
[InstanceEdit:9852959] Matthews, Lisa, 2023-11-08
[InstanceEdit:9860010] Matthews, Lisa, 2024-01-29
[InstanceEdit:9860955] Orlic-Milacic, Marija, 2024-02-13
[InstanceEdit:9861224] Orlic-Milacic, Marija, 2024-02-15
[InstanceEdit:9861225] Orlic-Milacic, Marija, 2024-02-15
[InstanceEdit:9861252] Orlic-Milacic, Marija, 2024-02-16
[InstanceEdit:9861361] Orlic-Milacic, Marija, 2024-02-16
[InstanceEdit:9863149] Orlic-Milacic, Marija, 2024-02-27
[InstanceEdit:9863524] Orlic-Milacic, Marija, 2024-03-01
[InstanceEdit:9907322] Orlic-Milacic, Marija, 2024-04-05
[InstanceEdit:9910918] Orlic-Milacic, Marija, 2024-05-23
nameKeratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis
output[Cell:9727357] keratinocyte of granulosum layer of epidermis [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[PositiveRegulation:158643] Positive regulation by 'Ca2+ [extracellular region]'
[NegativeRegulation:9839175] Negative regulation by 'O2 [extracellular region]'
[NegativeRegulation:9727662] Negative regulation by 'atRA [extracellular region]'
regulationReference[RegulationReference:9727664] Negative regulation by 'atRA [extracellular region]' Expression of loricrin is negatively controlled by retinoic acid in human epidermis reconstructed in vitro
[RegulationReference:9727658] Positive regulation by 'Ca2+ [extracellular region]' Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid
[RegulationReference:9839177] Negative regulation by 'O2 [extracellular region]' Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function
releaseDate2024-03-27
requiredInputComponent[EntityWithAccessionedSequence:1234135] HIF1A [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:452560] EPAS1 [nucleoplasm] [Homo sapiens]
[CandidateSet:9839179] Keratinocyte PKCs [cytosol] [Homo sapiens]
reviewed[InstanceEdit:9861092] Ganier, Clarisse, 2024-02-13
[InstanceEdit:9907436] Matthews, Lisa, 2024-04-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9727367] R-HSA-9727359.2
structureModified[InstanceEdit:9907322] Orlic-Milacic, Marija, 2024-04-05
summation[Summation:9839002] Spinous keratinocytes form 4-8 layers of cells in the stratu...
tissue[Anatomy:9725551] skin epidermis
(hasEvent)[CellLineagePath:9725554] Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin [Homo sapiens]
(precedingEvent)[CellDevelopmentStep:9727355] Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9911020] Update Tracker - [CellDevelopmentStep:9727359] Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis - v89:[add_removeRegulator, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (9727359)
Follow Reactome