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Details on Person XDH dehydrogenates hypoxanthine to form xanthine

Class:Id	Reaction:9727347
_displayName	XDH dehydrogenates hypoxanthine to form xanthine
_doRelease	TRUE
_timestamp	2025-12-10 22:50:00
authored	[InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
catalystActivity	[CatalystActivity:9727348] hypoxanthine dehydrogenase activity of XDH dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9727344] hypoxanthine dehydrogenase activity of XDH dimer [cytosol] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
crossReference	[DatabaseIdentifier:9976349] RHEA:24671
edited	[InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:113599] Hyp [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9727338] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans [LiteratureReference:200234] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase [LiteratureReference:500147] Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
modified	[InstanceEdit:9731153] D'Eustachio, Peter, 2021-05-13 [InstanceEdit:9731186] D'Eustachio, Peter, 2021-05-14 [InstanceEdit:9731210] D'Eustachio, Peter, 2021-05-17 [InstanceEdit:9758278] D'Eustachio, Peter, 2021-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	XDH dehydrogenates hypoxanthine to form xanthine hypoxanthine + NAD(+) + H2O => xanthine + NADH + H(+)
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:30064] XAN [cytosol]
precedingEvent	[Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens] [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine [Homo sapiens] [FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens] [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9731185] Jassal, Bijay, 2021-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9727351] R-HSA-9727347.4
summation	[Summation:9727346] Cytosolic xanthine dehydrogenase (XDH) in its dehydrogenase ...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:9727349] XDH dehydrogenates xanthine to form urate [Homo sapiens]
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