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Details on Person NPM1-ALK-dependent CEBPB gene expression

Class:IdBlackBoxEvent:9725357
_displayNameNPM1-ALK-dependent CEBPB gene expression
_doReleaseTRUE
_timestamp2023-10-12 19:31:29
authored[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:9725356] Rothfels, Karen, 2021-03-29
disease[Disease:1500689] cancer
[Disease:9699595] anaplastic large cell lymphoma
edited[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input[EntityWithAccessionedSequence:3858376] CEBPB gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9725240] Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
[LiteratureReference:9843138] NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9843134] C/EBPβ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway
[LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
modified[InstanceEdit:9725642] Rothfels, Karen, 2021-03-29
[InstanceEdit:9725655] Rothfels, Karen, 2021-03-30
[InstanceEdit:9725656] Rothfels, Karen, 2021-03-30
[InstanceEdit:9725658] Rothfels, Karen, 2021-03-30
[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9730718] Rothfels, Karen, 2021-05-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
nameNPM1-ALK-dependent CEBPB gene expression
output[EntityWithAccessionedSequence:381378] CEBPB [nucleoplasm] [Homo sapiens]
regulatedBy[PositiveRegulation:9725350] Positive regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]'
[PositiveGeneExpressionRegulation:9725337] Positive gene expression regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]'
[PositiveRegulation:9725343] Positive regulation by 'p-T,Y MAPK monomers and dimers [nucleoplasm]'
regulationReference[RegulationReference:9725638] Positive regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]' Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
[RegulationReference:9725639] Positive regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
[RegulationReference:9725634] Positive regulation by 'p-T,Y MAPK monomers and dimers [nucleoplasm]' Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9725358] R-HSA-9725357.3
summation[Summation:9725321] CEBPB is a transcription factor with roles in immune and inf...
(hasEvent)[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9853232] Update Tracker - [BlackBoxEvent:9725357] NPM1-ALK-dependent CEBPB gene expression - v87:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by NPM1-ALK-dependent CEBPB gene expression (9725357)
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